Reviews and Reflections on Lorenzo's Oil

Topics: Fatty acid, Adrenoleukodystrophy, Medicine Pages: 2 (629 words) Published: April 30, 2011
Review and reflections on Lorenz’s oil Movie

This is one of those films that sticks with us and there are scenes that I can never forget. Lorenzo's Oil is one of the best movies I have seen. Movie is about miracle cure to Adrenoleukodystrophy that gave hope to thousands of young children suffering with Adrenoleukodystrophy (ALD).  Movie is based on the true story of Augusto Odone, his wife, Michaela, their son, Lorenzo and their battle with ALD, a disease that attacks the central nervous system by systemically destroying the myelin sheath. It is an extremely rare disease that is transmitted exclusively to males through a gene that is carried by the mother.  

Augusto and Michaela are well educated couple blessed with a little son named Lorenzo who was precocious beyond his age. Lorenzo can speak English and Italian and his native language spoken in Africa. When Lorenzo returned to the United States at the age of five and his behavior started to change like over aggressive. Later Lorenzo, diagnosed as victim of ALD, an incurable degeneration of the brain, is beyond the help of conventional medicine.

Adrenoleukodystrophy is transmitted from parents to their children as an X-linked genetic trait. ALD is an inborn error of metabolism that causes the degeneration of the brain because of abnormally high level of fat in his blood, certain long-chain saturated fats .There is an enzyme that metabolizes these fats is defective in ALD patients. There is also liquefaction of white matter in the brain. This causes degeneration of the brain and the body loses its functions and death within two years of diagnosis.

No doctor is able to treat Lorenzo’s rare disease, that made Lorenzo’s parents to sought their own cure. They set out on a mission to find a treatment to save their child. In pursuit of their goal, Odones clashed with doctors, scientists, and support groups, who were skeptical that anything could be done about ALD, but they continued...
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