Autonomic nervous system
The autonomic nervous system (ANS or visceral nervous system) is the part of the peripheral nervous system that acts as a control system functioning largely below the level of consciousness, and controls visceral functions. The ANS affects heart rate, digestion, respiration rate, salivation, perspiration, diameter of the pupils, micturition (urination), and sexual arousal. Whereas most of its actions are involuntary, some, such as breathing, work in tandem with the conscious mind. It is classically divided into two subsystems: the parasympathetic nervous system (PSNS) and sympathetic nervous system (SNS).Relatively recently, a third subsystem of neurons that have been named 'non-adrenergic and non-cholinergic' neurons (because they use nitric oxide as a neurotransmitter) have been described and found to be integral in autonomic function, particularly in the gut and the lungs. With regard to function, the ANS is usually divided into sensory (afferent) and motor (efferent) subsystems. Within these systems, however, there are inhibitory and excitatory synapses between neurons. The enteric nervous system is sometimes considered part of the autonomic nervous system, and sometimes considered an independent system. Anatomy
ANS innervation is divided into sympathetic nervous system and parasympathetic nervous system divisions. The sympathetic division has thoracolumbar “outflow”, meaning that the neurons begin at the thoracic and lumbar (T1-L2) portions of the spinal cord. The parasympathetic division has craniosacral “outflow”, meaning that the neurons begin at the cranial nerves (CN 3, CN7, CN 9, CN10) and sacral (S2-S4) spinal cord. The ANS is unique in that it requires a sequential two-neuron efferent pathway; the preganglionic neuron must first synapse onto a postganglionic neuron before innervating the target organ. The preganglionic, or first, neuron will begin at the “outflow” and will synapse at the postganglionic, or second, neuron’s cell body. The post ganglionic neuron will then synapse at the target organ. Sympathetic division
The sympathetic division (thoracolumbar outflow) consists of cell bodies in the lateral horn of spinal cord (intermediolateral cell columns) of the spinal cord from T1 to L2. These cell bodies are GVE (general visceral efferent) neurons and are the preganglionic neurons. There are several locations upon which preganglionic neurons can synapse for their postganglionic neurons: Paravertebral ganglia of the sympathetic chain (these run on either side of the vertebral bodies) Prevertebral ganglia (celiac ganglia, superior mesenteric ganglia, inferior mesenteric ganglia) Chromaffin cells of adrenal medulla (this is the one exception to the two-neuron pathway rule: synapse is direct onto cell bodies) These ganglia provide the postganglionic neurons from which innervation of target organs follows. Examples of splanchnic (visceral) nerves are: Cervical cardiac nerves & thoracic visceral nerves which synapse in the sympathetic chain Thoracic splanchnic nerves (greater, lesser, least) which synapse in the prevertebral ganglion Lumbar splanchnic nerves which synapse in the prevertebral ganglion Sacral splanchnic nerves which synapse in the inferior hypogastric plexus These all contain afferent (sensory) nerves as well, also known as GVA (general visceral afferent) neurons. Parasympathetic division
The parasympathetic division (craniosacral outflow) consists of cell bodies from one of two locations: brainstem (Cranial Nerves III, VII, IX, X) or sacral spinal cord (S2, S3, S4). These are the preganglionic neurons, which synapse with postganglionic neurons in these locations: Parasympathetic ganglia of the head (Ciliary (CN III), Submandibular (CN VII), Pterygopalatine (CN VII), Otic (CN IX) In or near wall of organ innervated by Vagus (CN X), Sacral nerves (S2, S3, S4)) These ganglia provide the postganglionic neurons from which innervations of target organs follows. Examples...
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